Reader support helps keep the reviews honest and the site humming. As an Amazon Associate, I earn from qualifying purchases.7 Best Blackberry Bush Killer | Kills Blackberry Bushes for Good

Check Price on Amazon

A super-concentrate that reaches the root in two hours and shows visible results in three.

The defining feature here is speed. The manufacturer states that the active ingredients reach the roots in 1 to 2 hours and produce visible results in as little as 3 hours — a timeline that outpaces most brush killers on the shelf. Owners mention it works like a Roundup replacement at a lower cost, especially when used in an ATV sprayer for fence-line work. One reviewer noted, “Reaches the roots in 1 to 2 hours and provides visible results in as little as 3 hours.”

At 25.56 pounds for the 2.5-gallon jug (320.0 Fluid Ounces), this is a heavy-duty buy for serious infestations. You will need a sprayer accessory to apply it, and buyers caution that it will also kill grass, flowers, and any bug it contacts, so treat it as non-selective. The unit count of 320.0 Fluid Ounces vs a 32.0 Fluid Ounce RTU like Tordon represents a 10.0x gap in how much product you get, making this the volume king of the list.

Check Price on Amazon

A pasture-grade triclopyr concentrate that targets blackberry roots without harming grass.

Remedy is a top-rated pasture herbicide that uses triclopyr as its active ingredient, a selective brush killer that is especially effective on woody species like blackberry while leaving grass alive. The manufacturer states it is safe to use around children and pets when applied according to the label. Customers note it works best when mixed with diesel for basal bark application — one buyer mentioned, “took a couple of weeks to kill some small trees that kept coming back, but they’re gone now.” Another user who applied it on blackberry bushes and small trees confirmed the same formula mix works well.

At 1 gallon (128.0 Fluid Ounces), this is a mid-volume concentrate that costs more per ounce than the Hi-Yield Killzall II, but reviewers point out the selectivity makes it worth it for pasture and fence lines where you want to keep the grass. It does not work on general weeds or unwanted grass — one buyer admitted they chose the wrong product for their needs — so be sure your target is brush, not weeds. The low-odor formula is a practical bonus when you are working upwind.

Check Price on Amazon

A fast-acting brush killer that shrivels blackberry overnight and keeps working for up to two years.

Crossbow uses a triclopyr-based formula that buyers describe as devastatingly fast. One owner reported: “Kills everything sprayed within 24 hours; shriveled by next day, dead by day two.” That speed is paired with residual soil activity that lasts up to 2 years according to the same buyer, meaning you do not have to reapply after every rain. The gallon size covers approximately 1 acre or less, which suits medium-sized patches well.

This product is heavier than the BioAdvanced RTU at 11 pounds for the same 1-gallon volume (128.0 Fluid Ounces), but one experienced buyer noted that the standard formula contains only 16.5 percent triclopyr — they bought a gallon of pure Garlon triclopyr at 61.6 percent to boost the strength for woody brush and blackberries. So while it works well out of the bottle, heavy infestations may benefit from a secondary booster. The strong chemical smell is noted by buyers as a confirmation it is working, but apply on calm days only.

Check Price on Amazon

A one-gallon concentrate that stretches to 17,200 square feet — enormous value for spreading across whole fields.

The headline number here is coverage: 17,200 square feet per bottle when mixed at the spot-control rate of 6 oz per gallon of water. That is a massive treating area for a 1-gallon concentrate, giving it the best cost-per-square-foot in this lineup. Buyers confirm its blackberry-fighting reputation. One customer observed, “This stuff is amazing in the battle of blackberry intrusion.” They use it to kill weeds coming from an overgrown abandoned property next door. Another buyer noted it remains effective even after rain the next day, which is a practical advantage for unpredictable weather.

Compared to the Killzall II (2.5 gal), this is a smaller volume but the same brand and similar non-selective action. One user went through two full bottles in a year, spraying three or four times, and still considered it more cost-effective than store brands. It is rain-resistant after drying, which adds flexibility compared to products that need 24-48 hours of dry weather. The catch: the label says “do not use on lawns,” because it kills grass just as effectively as it kills brush.

Check Price on Amazon

A ready-to-use spray that claims to stop brush regrowth for up to 365 days from a single treatment.

This is the only ready-to-use spray in the premium half of the list, which means you do not need a sprayer — just twist the nozzle and apply until the leaves are wet. The label says it kills tough brush like blackberry, bamboo, and poison ivy down to the root for up to 12 months. One user highlighted it “killed bush regrowth after 2 months with no regrowth,” though not all experiences match the 365-day claim. It treats up to 500 square feet, so know that a 1-gallon bottle covers a relatively small area compared to concentrates.

At 8.5 pounds, this is the lightest full-gallon product on the list — the Killzall II (2.5 gal) weighs 25.56 pounds, a 3.0x weight gap that matters if you are carrying the bottle across a field. But the unit count is 128.0 Fluid Ounces vs the 320.0 Fluid Ounces of the Killzall II, which is a 2.5x volume difference in favor of the concentrate. The slow-kill systemic action (1-28 days for visible results) is a trade-off: one buyer who gave it 1/5 stars found it ineffective after three applications on bamboo and saplings, calling it a “waste of money.” So while many succeed, results may vary by species and condition.

Check Price on Amazon

A two-active-ingredient concentrate that covers 2.23 acres per bottle and works fast on broadleaf brush.

Southern Ag Crossbow combines Garlon and 2,4-D as its active ingredients, making it a broader-spectrum brush killer than a straight triclopyr product. The label says it makes up to 96 gallons of spray solution and covers 2.23 acres — by far the largest coverage claim on this list. Buyers who have used it for years call it “super effective.” One noted it killed all overgrowth including ivy, vines, 8-foot weeds, small trees, bushes, and grass within 48 hours, with complete die-off in one week. That is competitive with the Crossbow brand above but at a slightly different active-ingredient mix.

One reviewer, who compared it directly to Roundup, said it is “safer than Roundup with a 3-day soil half-life” and noted it contains no glyphosates or neonicotinoids. They recommend applying it at a 1% solution, which takes roughly one week to show results. A different buyer noted that efficacy varies significantly by soil type: 85% kill in Ohio brown soil, but only 30-35% in rich Illinois soil. This suggests local conditions matter more with this formula than with some others. The strong odor is a recurring comment — gloves and a mask are wise.

Check Price on Amazon

A small, powerful RTU that one reviewer calls “the magic bullet” against invasive weed trees and stumps.

At 32.0 Fluid Ounces, this is the smallest product in the lineup — just 1 quart. But buyers are emphatic about its potency. One reviewer warned, “USE CAREFULLY. Seriously this stuff kills anything. It’s the magic bullet you’ve been waiting for in your fight against weed trees.” Another found it effective against buckthorn and honeysuckle, confirming it kills the root on everything used on it. The size makes sense for stump treatment: one buyer simply painted it on cut stumps to stop them from resprouting, and it worked perfectly.

The liquid volume of 1 Quart (32.0 Fluid Ounces) puts it at a 10.0x deficit compared to the Killzall II (320.0 Fluid Ounces), so this is not the choice for acres of blackberry. But for someone cutting down a few large bushes and treating the stumps to prevent regrowth, a quart can last months. The manufacturer labels it for invasive species and non-selective broad spectrum coverage. There is no mixing — it is true point-and-spray RTU. The downside is that at this small size, you pay a big premium per ounce compared to any concentrate.