6 Best All Natural Pesticide | Skip the Toxic Sprays

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A fungus-fighting concentrate that saves trees and rose bushes without synthetic chemicals.

If powdery mildew, black spot, or blight is ruining your ornamentals, this citric-acid based fungicide targets the disease directly. The formula is OMRI Listed for organic gardening, so you can spray it on fruits and vegetables right up to the day you harvest. It comes as a 32 oz concentrate—you mix 6 tablespoons into 1 gallon of water—and one bottle makes 10 full gallons of ready-to-use spray, which is far more economical than buying pre-mixed bottles.

Buyers report serious results. One reviewer noted that the product “saved a Palo Verde tree from root fungus after two deep soil treatments” with the tree greening up within a week. Another said their rose leaves look “MUCH healthier” after using it. At 2.26 pounds, this bottle is noticeably heavier than the 1.26-pound peppermint oil sprays, but that extra weight comes from a concentrated formula that goes a lot further. The trade-off is that you need a sprayer and a little measuring time, unlike the ready-to-use options below.

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A biological weapon that kills only leaf-eating worms while leaving bees and birds alone.

This is the most targeted pesticide in the lineup. It uses Bacillus thuringiensis (B.t.), a naturally occurring soil bacterium that, when eaten by caterpillars, produces a protein that stops them from feeding. It does absolutely nothing to bees, earthworms, or ladybugs—making it the safest choice for flowering vegetable gardens. The 32 oz bottle is ready-to-use with a trigger sprayer, so you do not need to mix anything.

Monterey B.t. is OMRI Listed (certified for organic gardening), and reviewers confirm it works fast. One buyer mentioned it “effectively eliminated cabbage loopers” that had destroyed their flower seedlings the previous year, while another noted it “got rid of the little caterpillars eating my Texas Laurel.” The catch is its narrow focus: it only kills caterpillars and worm-type insects (cabbage looper, bagworm, gypsy moth, fall cankerworm, elm spanworm). If you have aphids, mites, or fungus, you need a different product.

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A dual-action spray that nukes spider mites and powdery mildew without measuring a thing.

Athena IPM is a rare hybrid: it works as both a fungicide (for powdery mildew) and an insecticide (for spider mites, aphids, and thrips). It uses EPA 25(b) minimum risk ingredients, meaning the EPA has reviewed it and classified its components as safe enough to be exempt from standard pesticide registration—so no harsh synthetic chemicals. The 32 oz bottle is ready-to-use: just shake and spray, no mixing or special equipment required.

Buyers praise its broad effectiveness. One reviewer called it “the best of the best” for battling pests that come dormant in grow media, adding that it “zaps mites as well as all the other critters that cause problems.” Another said it is “literally the best product I’ve used so far” for marijuana plants. It is trusted by both professional commercial cultivators and home gardeners. Unlike the Earth’s Ally concentrate above, this is a ready-to-use liquid, so you pay a premium for convenience—you do not get the 10-gallon yield of the concentrate.

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A minty home defense that drives away spiders and ants without staining your baseboards.

If your main problem is spiders web-building in corners or ants marching across the kitchen counter, this peppermint-oil spray is your simplest solution. It is plant-based and safe around pets and family when used as directed—no harsh fumes or chemical smell. The 16 oz bottle sprays a fine mist that dries quickly and leaves no sticky residue, so you can use it on baseboards, entryways, patios, and garages without worrying about stains.

Reviewers consistently report a “significant decrease in spiders and cobwebs” after just a few days of use. One owner reported the “pleasant natural aroma” and said the spray is “easy to apply” both indoors and outdoors. At 1.26 pounds, it is significantly lighter than the Earth’s Ally concentrate (2.26 pounds), making it easier to carry around the house during a full perimeter spray session. The main trade-off is that it is a repellent and contact killer, not a long-term residual poison—you will need to reapply after rain or heavy cleaning.

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The extra-concentrated peppermint spray that sends mice, bats, and wasps packing.

This spray stands apart because it also targets rodents—mice, rats, and even bats—not just insects. The “extra strength” label means a higher concentration of pure peppermint essential oil compared to standard peppermint sprays, which is what makes it effective against larger pests that are usually harder to deter naturally. It is ready-to-use with no mixing required, and the 16 oz bottle covers both indoor and outdoor areas.

Buyers have found creative uses. One customer observed it “works great if you are having a bat issue”—they soaked the area where bats were flying in and out of their awning and reapplied over a few days, and the bats stopped coming. Another reviewer uses it on a farm and says it “pretty much eliminate the issue” with flies around door frames. A third noted it is safe around their two dogs and effective on crickets, camel spiders, ants, and aphids in the garden. The downside is that the strong peppermint concentration can be too intense for some—one reviewer had a spill from a warm bottle, so let it cool before securing the nozzle.

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A dust-on-contact powder that dehydrates crawling insects without poisons or fumes.

Diatomaceous earth (DE) is the fossilized remains of tiny aquatic organisms called diatoms. The microscopic sharp edges cut into the exoskeleton of crawling insects like ants, roaches, fleas, silverfish, and bedbugs, causing them to dehydrate and die. This RobiGuard blend mixes food-grade DE with peppermint oil powder—the peppermint acts as an attractant and adds a repellent scent. The 16 oz pouch is light at 0.55 kilograms (about 1.2 pounds) and comes in a resealable bag.

Buyers love its humane side. One user highlighted the “food-grade DE & peppermint powder mix effectively repelled squirrels from rose garden without harming them.” Another noted it “reduced gnats and fleas” in their home, and after one week the gnats were “nearly gone.” A third reviewer uses it for “ants, slugs, fleas” and says it is “safe for pets.” The trade-off is that it is a fine powder—reviewers recommend wearing a mask during application because the dust can irritate lungs. It also stops working when wet, so it is best for dry indoor areas or covered outdoor spots.